Do cognitive reserve levels affect brain glucose metabolism and amyloid-β depositions in subjective cognitive decline subjects?

Subjective cognitive decline (SCD) is the preclinical stage of Alzheimer's disease (AD). Abnormal brain glucose metabolism and Aβ depositions can be observed in SCD subjects. Nevertheless, there was not cognitive impaired performance in standardized neuropsychological in these subjects. Cognitive reserve (CR) could be the reason to explain this phenomenon. However, correspondence between CR and SCD was still uncleared. In this study, we attained 74 subjects underwent 18FFDG PET scans (SCD1 group) and 38 patients underwent 18FAV45 PET scans (SCD2 group) from Xuanwu Hospital, Beijing, China. First, SCD1 group was divided into SCD1H (high CR, n=33, educational years>12) and SCD1L (low CR, n=41, educational years 12) and SCD2L (low CR, n=21, educational years