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The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?
- Source :
- Clinical and Experimental Immunology. 188:1-11
- Publication Year :
- 2017
- Publisher :
- Oxford University Press (OUP), 2017.
-
Abstract
- SummaryMesenchymal stromal cells (MSC) have emerged as promising cell therapies for multiple conditions based on demonstrations of their potent immunomodulatory and regenerative capacities in models of inflammatory disease. Understanding the effects of MSC on T cells has dominated the majority of work carried out in this field to date; recently, however, a number of studies have shown that the therapeutic effect of MSC requires the presence of macrophages. It is timely to review the mechanisms and manner by which MSC modulate macrophage populations in order to design more effective MSC therapies and clinical studies. A complex cross-talk exists through which MSC and macrophages communicate, a communication that is not controlled exclusively by MSC. Here, we examine the evidence that suggests that MSC not only respond to inflammatory macrophages and adjust their secretome accordingly, but also that macrophages respond to encounters with MSC, creating a feedback loop which contributes to the immune regulation observed following MSC therapy. Future studies examining the effects of MSC on macrophages should consider the antagonistic role that macrophages play in this exchange.
- Subjects :
- 0301 basic medicine
Future studies
Stromal cell
T-Lymphocytes
Immunology
Cell
Cell- and Tissue-Based Therapy
Inflammation
Review Article
Cell Communication
Mesenchymal Stem Cell Transplantation
Immunomodulation
Cell therapy
03 medical and health sciences
medicine
Animals
Humans
Immunology and Allergy
Macrophage
business.industry
Macrophages
Mesenchymal stem cell
Immune regulation
Cell Differentiation
Mesenchymal Stem Cells
Phenotype
030104 developmental biology
medicine.anatomical_structure
Cytokines
Inflammation Mediators
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 13652249 and 00099104
- Volume :
- 188
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....4dea54550948dc4bdec29408b5a02f21
- Full Text :
- https://doi.org/10.1111/cei.12929