Back to Search
Start Over
Regional and systemic prophylaxis with teicoplanin in total knee arthroplasty: a tissue penetration study
- Source :
- The Journal of arthroplasty. 18(3)
- Publication Year :
- 2003
-
Abstract
- Five patients undergoing total knee arthroplasty (TKA) received 800 mg intravenous teicoplanin systemically 2.5 hours before surgery and 15 patients received 200 mg teicoplanin into a foot vein in the leg to be treated. Samples of bone, synovia, subcutaneous tissue, and skin were collected at 20, 40, and 60 minutes after tourniquet inflation and at the end of surgery. None of the study subjects experienced adverse effects, adverse events, or infections during the postoperative and follow-up period. Mean teicoplanin concentration in the collected tissue ranged from 1.52 to 5.81 mg/L after regional prophylaxis and from 0.9 to 2.94 mg/L after systemic prophylaxis. Bone and soft tissue penetration of teicoplanin after regional prophylaxis with 200 mg is at least comparable with that achieved after systemic prophylaxis with 800 mg. Regional prophylaxis in TKA appears to be safe and valuable. Higher dosages of teicoplanin seem to be needed to ensure coverage against coagulase negative staphylococci.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Bone and Bones
Subcutaneous Tissue
medicine
Humans
Surgical Wound Infection
Orthopedics and Sports Medicine
Antibiotic prophylaxis
Vein
Adverse effect
Arthroplasty, Replacement, Knee
Infusions, Intravenous
Aged
Skin
Tourniquet
business.industry
Teicoplanin
Foot
Synovial Membrane
Soft tissue
Antibiotic Prophylaxis
Arthroplasty
Surgery
Anti-Bacterial Agents
Forearm
medicine.anatomical_structure
Anesthesia
Injections, Intravenous
Female
business
Subcutaneous tissue
medicine.drug
Subjects
Details
- ISSN :
- 08835403
- Volume :
- 18
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of arthroplasty
- Accession number :
- edsair.doi.dedup.....4de3c6417a8c4024af1f5500fd3dd278