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The histologic detection of Helicobacter pylori in seropositive subjects is affected by pathology and secretory ability of the stomach
- Source :
- Helicobacter. 23:e12480
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- BACKGROUND Helicobacter pylori is unevenly distributed in hypochlorhydric environments. The study aim was to elucidate the risk factors for a negative Giemsa staining finding in seropositive subjects by measuring the secretory ability of the stomach. METHODS Subjects aged over 18 years were included consecutively after endoscopic biopsy at gastric lesions with color or structural changes. Blood was sampled for the serum pepsinogen (PG) assay and H. pylori serology test. After excluding the subjects with past H. pylori eradication, the risk factors for a negative Giemsa staining finding in seropositive subjects were analyzed. RESULTS Among 872 included subjects, a discrepancy between the serum anti-H. pylori IgG and Giemsa staining findings was found in 158 (18.1%) subjects, including 145 Giemsa-negative, seropositive subjects. Gastric adenocarcinoma/adenoma (OR = 11.090, 95% CI = 3.490-35.236) and low serum PG II level (OR = 0.931, 95% CI = 0.899-0.963) were the independent risk factors for a negative Giemsa staining finding in seropositive subjects. The cutoff value of serum PG II level was 7.45 ng/mL (area under curve [AUC] = 0.904, 95% CI = 0.881-0.927). Follow-up studies of Giemsa staining at different sites of the stomach revealed that 75% of the Giemsa-negative seropositive subjects with adenocarcinoma are positive, whereas none of those with low serum PG II level of
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Giemsa stain
Helicobacter Infections
Serology
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Biopsy
medicine
Humans
Stomach cancer
Aged
Aged, 80 and over
Helicobacter pylori
Pepsinogens
Staining and Labeling
biology
medicine.diagnostic_test
business.industry
Stomach
Gastroenterology
General Medicine
Middle Aged
medicine.disease
biology.organism_classification
Antibodies, Bacterial
Infectious Diseases
medicine.anatomical_structure
Gastric Mucosa
030220 oncology & carcinogenesis
Adenocarcinoma
Female
030211 gastroenterology & hepatology
Histopathology
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 10834389
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Helicobacter
- Accession number :
- edsair.doi.dedup.....4de2e362612b2178144f8cdeeda7ec67