Establishment of a human iPSC line, IISHDOi004-A, from a patient with Usher syndrome associated with the mutation c.2276G>T; p.Cys759Phe in the USH2A gene

A human iPSC line, IISHDOi004-A, from fibroblasts obtained from a patient with Usher syndrome, harboring a homozygous mutation in the USH2A gene (c.2276G>T; p.Cys759Phe) has been generated. Reprogramming factors Oct3/4, Sox2, Klf4, and c-Myc were delivered using Sendai virus.
This work was supported by grants from: 1) the “Fondo de Investigación Sanitaria, Instituto de Salud Carlos III cofunded by FEDER Funds”: PI10/0703, PI13/00556 and PI16/00789 to RG, PI15/00484 to MEG and PI16/0425 to CA. 2) “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER): grants 13-717/132.05 and ER16P3AC717 to RG. 3) “Comunidad Autónoma de Madrid” (grant number S2010/BMD-2402 to RG) and 4) FUNDALUCE 2015 to CA. MdC.O-C and F.Z-D receive grant support from the Ministerio de Educación, Cultura y Deporte (FPU13/00544 and FPU16/03895). MEG is supported by a “Miguel Servet” contract (CP16/00046) from Instituto de Salud Carlos III and FEDER Funds. LG is supported by a “Rio Hortega” contract (16/00126) from Instituto de Salud Carlos III and FEDER Funds.