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Longitudinal Changes of Fixation Location and Stability Within 12 Months in Stargardt Disease: ProgStar Report No. 12
- Source :
- American Journal of Ophthalmology. 193:54-61
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Purpose To investigate the natural history of Stargardt disease (STGD1) using fixation location and fixation stability. Design Multicenter, international, prospective cohort study. Methods Fixation testing was performed using the Nidek MP-1 microperimeter as part of the prospective, multicenter, natural history study on the Prog ression of Star gardt disease (ProgStar). A total of 238 patients with ABCA4-related STGD1 were enrolled at baseline (bilateral enrollment in 86.6%) and underwent repeat testing at months 6 and 12. Results Outcome measures included the distance of the preferred retinal locus from the fovea (PRL) and the bivariate contour ellipse area (BCEA). After 12 months of follow-up, the change in the eccentricity of the PRL from the anatomic fovea was −0.0014 degrees (95% confidence interval [CI], −0.27 degrees, 0.27 degrees; P = .99). The deterioration in the stability of fixation as expressed by a larger BCEA encompassing 1 standard deviation of all fixation points was 1.21 degrees squared (deg2) (95% CI, −1.23 deg2, 3.65 deg2; P = .33). Eyes with increases and decreases in PRL eccentricity and/or BCEA values were observed. Conclusions Our observations point to the complexity of fixation parameters. The association of increasingly eccentric and unstable fixation with longer disease duration that is typically found in cross-sectional studies may be countered within individual patients by poorly understood processes like neuronal adaptation. Nevertheless, fixation parameters may serve as useful secondary outcome parameters in selected cases and for counseling patients to explain changes to their visual functionality.
- Subjects :
- Adult
Male
Fixation stability
medicine.medical_specialty
Adolescent
Visual Acuity
Fixation, Ocular
Retina
Article
Standard deviation
Macular Degeneration
Young Adult
03 medical and health sciences
0302 clinical medicine
Ophthalmology
medicine
Humans
Stargardt Disease
Prospective Studies
Young adult
Child
Prospective cohort study
Aged
business.industry
Middle Aged
medicine.disease
Confidence interval
Stargardt disease
Fixation (visual)
030221 ophthalmology & optometry
Visual Field Tests
Female
Visual Fields
business
030217 neurology & neurosurgery
Natural history study
Follow-Up Studies
Subjects
Details
- ISSN :
- 00029394
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- American Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....4dc1fe9a946f9b63f1bd9660c98d914d