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Coccidioidomycosis in the Acquired Immunodeficiency Syndrome
- Source :
- Annals of Internal Medicine. 106:372
- Publication Year :
- 1987
- Publisher :
- American College of Physicians, 1987.
-
Abstract
- Of 27 patients with the acquired immunodeficiency syndrome (AIDS) in Tucson, Arizona, 7 had concurrent coccidioidomycosis. Early manifestations of infection in 6 patients included diffuse nodular pulmonary infiltrates and Coccidioides immitis in many extrathoracic sites. By comparison, a retrospective review of the cases of 300 patients hospitalized with coccidioidal infection identified only 13 patients without AIDS who had the same extent of infection, and only 3 of these patients had no immunosuppressing conditions. Antibodies for coccidioidal antigens at serum dilutions as high as 1:2048 were detected in 5 of the 7 patients with AIDS. Six had temporary responses to amphotericin B treatment, taken both alone and combined with ketoconazole, but all died within 14 months of their diagnosis of coccidioidomycosis. Because annual rates of coccidioidal infection in the Tucson area are 4% or less, the rate of 27% that we calculated, based on 7 patients having the infection during 26 years of risk for AIDS, suggests frequent reactivation of the infection or enhanced susceptibility to endemic exposure in persons with AIDS.
- Subjects :
- Adult
Male
medicine.medical_specialty
Coccidioides immitis
Acquired immunodeficiency syndrome (AIDS)
Amphotericin B
Immunopathology
Internal Medicine
medicine
Humans
Mycosis
Retrospective Studies
Acquired Immunodeficiency Syndrome
Coccidioidomycosis
Lung Diseases, Fungal
biology
business.industry
Arizona
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
biology.organism_classification
Dermatology
Ketoconazole
Immunology
Viral disease
business
medicine.drug
Subjects
Details
- ISSN :
- 00034819
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- Annals of Internal Medicine
- Accession number :
- edsair.doi.dedup.....4dc0e42f5131d5f77e73be97c15c246b
- Full Text :
- https://doi.org/10.7326/0003-4819-106-3-372