Production of a Murine Monoclonal Antibody to the Low-Incidence Red Cell Antigen Wra: Characterisation and Comparison with Human Anti-Wra

The production of a monoclonal antibody which detects the low-incidence red cell antigen Wr(a) is described. The antibody (BGU1-WR) was isolated following immunization of BALB/tk mice with Wr(a+) cells. BGU1-WR is an IgG1 antibody and reacted in a manner similar to human polyclonal anti-Wr(a) with untreated, protease treated and chemically modified Wr(a+) cells.