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Vitamin C Prevents Hypogonadal Bone Loss
- Source :
- PLoS ONE, PLoS ONE, Vol 7, Iss 10, p e47058 (2012)
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Epidemiologic studies correlate low vitamin C intake with bone loss. The genetic deletion of enzymes involved in de novo vitamin C synthesis in mice, likewise, causes severe osteoporosis. However, very few studies have evaluated a protective role of this dietary supplement on the skeleton. Here, we show that the ingestion of vitamin C prevents the low-turnover bone loss following ovariectomy in mice. We show that this prevention in areal bone mineral density and micro-CT parameters results from the stimulation of bone formation, demonstrable in vivo by histomorphometry, bone marker measurements, and quantitative PCR. Notably, the reductions in the bone formation rate, plasma osteocalcin levels, and ex vivo osteoblast gene expression 8 weeks post-ovariectomy are all returned to levels of sham-operated controls. The study establishes vitamin C as a skeletal anabolic agent.
- Subjects :
- medicine.medical_specialty
Anatomy and Physiology
Bone density
Ovariectomy
Osteoporosis
lcsh:Medicine
Ascorbic Acid
Bone resorption
Mice
Bone Density
Internal medicine
Animals
Medicine
lcsh:Science
Bone
Biology
Musculoskeletal System
Nutrition
Bone mineral
Multidisciplinary
Vitamin C
biology
business.industry
lcsh:R
Osteoblast
Vitamins
medicine.disease
Ascorbic acid
Mice, Inbred C57BL
Radiography
medicine.anatomical_structure
Endocrinology
Osteocalcin
biology.protein
lcsh:Q
Female
business
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....4d9af817ed585c9485aa09f6ba9fb90b