Back to Search
Start Over
Interfacial engineered gadolinium oxide nanoparticles for magnetic resonance imaging guided microenvironment-mediated synergetic chemodynamic/photothermal therapy
- Source :
- Biomaterials. 219
- Publication Year :
- 2019
-
Abstract
- Engineering interfacial structure of biomaterials have drawn much attention due to it can improve the diagnostic accuracy and therapy efficacy of nanomedicine, even introducing new moiety to construct theranostic agents. Nanosized magnetic resonance imaging contrast agent holds great promise for the clinical diagnosis of disease, especially tumor and brain disease. Thus, engineering its interfacial structure can form new theranostic platform to achieve effective disease diagnosis and therapy. In this study, we engineered the interfacial structure of typical MRI contrast agent, Gd2O3, to form a new theranostic agent with improved relaxivity for MRI guided synergetic chemodynamic/photothermal therapy. The synthesized Mn doped gadolinium oxide nanoplate exhibit improved T1 contrast ability due to large amount of efficient paramagnetic metal ions and synergistic enhancement caused by the exposed Mn and Gd cluster. Besides, the introduced Mn element endow this nanomedicine with the Fenton-like ability to generate OH from excess H2O2 in tumor site to achieve chemodynamic therapy (CDT). Furthermore, polydopamine engineered surface allow this nanomedicine with effective photothermal conversion ability to rise local temperature and accelerate the intratumoral Fenton process to achieve synergetic CDT/photothermal therapy (PTT). This work provides new guidance for designing magnetic resonance imaging guided synergetic CDT/PTT to achieve tumor detection and therapy.
- Subjects :
- Materials science
Indoles
Cell Survival
Polymers
MRI contrast agent
Biophysics
Nanoparticle
Contrast Media
Mice, Nude
Bioengineering
Nanotechnology
Antineoplastic Agents
Gadolinium
02 engineering and technology
Polyethylene Glycols
Biomaterials
03 medical and health sciences
Superoxides
Cell Line, Tumor
Neoplasms
medicine
Tumor Microenvironment
Animals
Humans
030304 developmental biology
0303 health sciences
medicine.diagnostic_test
Lasers
Magnetic resonance imaging
Hyperthermia, Induced
Photothermal therapy
Phototherapy
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
Brain disease
Nanostructures
Tumor detection
Mechanics of Materials
Ceramics and Composites
Nanomedicine
Nanoparticles
Gadolinium oxide
0210 nano-technology
Subjects
Details
- ISSN :
- 18785905
- Volume :
- 219
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....4d93353983ac23c33cd16ec2fb2354e3