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Creutzfeldt-Jakob disease with amyloid angiopathy: diagnosis by immunological analyses and transmission experiments
- Source :
- Acta Neuropathologica. 83:559-563
- Publication Year :
- 1992
- Publisher :
- Springer Science and Business Media LLC, 1992.
-
Abstract
- It was difficult to make a definite pathological diagnosis in a 73-year-old man with Creutzfeldt-Jakob disease (CJD) due to extensive amyloid angiopathy which lacked any severe spongiform changes. Immunostaining using anti-prion protein (PrP) antibody revealed fine granular deposits in the gray matter, after hydrolytic autoclaving pretreatment on tissue sections. Western blotting also revealed an abnormal isoform of PrP, but PrP gene analysis did not show any abnormalities. The primary transmission experiments were repeated three times and induced spongiform encephalopathy in a few mice after a long incubation period.
- Subjects :
- Electrophoresis
Male
Gene isoform
Pathology
medicine.medical_specialty
Prions
animal diseases
Blotting, Western
Mice, Inbred Strains
Disease
Creutzfeldt-Jakob Syndrome
Pathology and Forensic Medicine
Incubation period
Mice
Cellular and Molecular Neuroscience
mental disorders
Animals
Humans
Medicine
Pathological
Aged
Amyloid beta-Peptides
Paraffin Embedding
biology
business.industry
Immunohistochemistry
nervous system diseases
Blot
Cerebral Amyloid Angiopathy
Mice, Inbred CBA
biology.protein
Female
Neurology (clinical)
Antibody
business
Immunostaining
Subjects
Details
- ISSN :
- 14320533 and 00016322
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Acta Neuropathologica
- Accession number :
- edsair.doi.dedup.....4d92e0c5a255b2588cad7d942f1633fb
- Full Text :
- https://doi.org/10.1007/bf00310037