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Creutzfeldt-Jakob disease with amyloid angiopathy: diagnosis by immunological analyses and transmission experiments

Authors :
Tetsuyuki Kitamoto
Katsumi Doh-ura
Jun Tateishi
J. W. Boellaard
J. Peiffer
Source :
Acta Neuropathologica. 83:559-563
Publication Year :
1992
Publisher :
Springer Science and Business Media LLC, 1992.

Abstract

It was difficult to make a definite pathological diagnosis in a 73-year-old man with Creutzfeldt-Jakob disease (CJD) due to extensive amyloid angiopathy which lacked any severe spongiform changes. Immunostaining using anti-prion protein (PrP) antibody revealed fine granular deposits in the gray matter, after hydrolytic autoclaving pretreatment on tissue sections. Western blotting also revealed an abnormal isoform of PrP, but PrP gene analysis did not show any abnormalities. The primary transmission experiments were repeated three times and induced spongiform encephalopathy in a few mice after a long incubation period.

Details

ISSN :
14320533 and 00016322
Volume :
83
Database :
OpenAIRE
Journal :
Acta Neuropathologica
Accession number :
edsair.doi.dedup.....4d92e0c5a255b2588cad7d942f1633fb
Full Text :
https://doi.org/10.1007/bf00310037