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Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats
- Source :
- Magnesium Research. 34:9-19
- Publication Year :
- 2021
- Publisher :
- John Libbey Eurotext, 2021.
-
Abstract
- The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1, or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg BW for 35 days. Neither form of biotin influenced (p > 0.05) serum glucose or insulin concentrations. Serum total cholesterol and triglyceride decreased with biotin from both sources (p < 0.05). Concentrations were lower with magnesium biotinate when comparing the 1 mg/kg dose (p < 0.05). Serum, liver, and brain biotin and liver cyclic guanosine monophosphate (cGMP) concentrations were greater when rats were treated with magnesium biotinate versus d-biotin, particularly when comparing the 1 and 100 mg/kg dose groups (p < 0.05). Both biotin forms decreased the liver SREBP-1c and FAS and increased AMPK-alpha 1, ACC-1, ACC-2, PCC, and MCC levels (p < 0.05). The magnitudes of responses were more emphasized with magnesium biotinate. Magnesium biotinate, compared with a commercial d-biotin, is more effective in reducing serum lipid concentrations and regulating protein levels of lipid metabolism-related biomarkers.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
medicine.medical_treatment
Clinical Biochemistry
Biotin
chemistry.chemical_element
Biochemistry
Rats, Sprague-Dawley
chemistry.chemical_compound
Internal medicine
medicine
Animals
Insulin
Magnesium
Molecular Biology
Cyclic guanosine monophosphate
Dose-Response Relationship, Drug
medicine.diagnostic_test
Triglyceride
Body Weight
Proteins
Lipid metabolism
Lipid Metabolism
Rats
Endocrinology
Liver
chemistry
Dietary Supplements
Lipid profile
Egg white
Subjects
Details
- ISSN :
- 19524021 and 09531424
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Magnesium Research
- Accession number :
- edsair.doi.dedup.....4d904b61fa73afa90427e65e803b4b43