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Role of 18F-DOPA PET/CT imaging in congenital hyperinsulinism
- Source :
- Reviews in Endocrine and Metabolic Disorders. 11:165-169
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Congenital hyperinsulinism is a leading cause of severe hypoglycaemia in the newborn period. There are two (diffuse and focal) histological subtypes of congenital hyperinsulinism. The diffuse form affects the entire pancreas and if medically unresponsive will require a near total (95%-98%) pancreatectomy. The focal form affects only a small region of the pancreas (with the rest of the pancreas being normal in endocrine and exocrine function) and only requires a limited pancreatectomy. This limited section of the focal lesion has the potential for curing the patient. Thus the pre-operative differentiation of these two subgroups is extremely important. Recent advances in Fluorine-18-L-dihydroxyphenylalanine positron emission tomography ((18)F-DOPA PET/CT) have radically changed the clinical approach to patient with congenital hyperinsulinism. In most patients this novel imaging technique is able to offer precise pre-operative localisation of the focal lesion, thus guiding the extent of surgical resection.
- Subjects :
- Pathology
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Pet ct imaging
Hypoglycemia
Models, Biological
Endocrinology
Humans
Medicine
Endocrine system
medicine.diagnostic_test
business.industry
Infant, Newborn
medicine.disease
Dihydroxyphenylalanine
18f dopa
medicine.anatomical_structure
Positron emission tomography
Positron-Emission Tomography
Pancreatectomy
Congenital hyperinsulinism
Congenital Hyperinsulinism
business
Pancreas
Tomography, Emission-Computed
Subjects
Details
- ISSN :
- 15732606 and 13899155
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Reviews in Endocrine and Metabolic Disorders
- Accession number :
- edsair.doi.dedup.....4d8eb2a5a723d154554ce77fd4bda219
- Full Text :
- https://doi.org/10.1007/s11154-010-9145-1