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Combined Effects of Simultaneous Exposure to Toluene and Ethanol on Auditory Function in Rats
- Source :
- Neurotoxicology and Teratology. 20:321-332
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the second one was daily gavaged with a saline solution of ethanol (4 g/kg, 4 weeks), and the last group was simultaneously exposed to both toluene and ethanol. Auditory function was tested by recording brain stem (inferior colliculus) auditory-evoked potentials for audiometric frequencies ranging from 2 to 32 kHz. Urinary hippuric acid was dosed to check the toluene metabolism during the experiments. Ethanol clearly modified the toluene metabolism in the present experimental conditions. As a result, the hearing loss induced by a simultaneous exposure to both ethanol and toluene was larger than that induced by exposure to toluene alone.
- Subjects :
- Inferior colliculus
Time Factors
medicine.medical_treatment
Toxicology
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Audiometry
Developmental Neuroscience
Oral administration
Evoked Potentials, Auditory, Brain Stem
medicine
Animals
Saline
Analysis of Variance
Ethanol
Chromatography
Inhalation
Chemistry
Hippurates
Hippuric acid
Toluene
Rats
Anesthesia
Toxicity
Microscopy, Electron, Scanning
Subjects
Details
- ISSN :
- 08920362
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Neurotoxicology and Teratology
- Accession number :
- edsair.doi.dedup.....4d82ca18f27f26e921e0abde65e70800