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Disinfection of human cardiac valve allografts in tissue banking: systematic review report
- Source :
- Cell and Tissue Banking
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Cardiovascular allografts are usually disinfected using antibiotics, but protocols vary significantly between tissue banks. It is likely that different disinfection protocols will not have the same level of efficacy; they may also have varying effects on the structural integrity of the tissue, which could lead to significant differences in terms of clinical outcome in recipients. Ideally, a disinfection protocol should achieve the greatest bioburden reduction with the lowest possible impact on tissue integrity. We conducted a systematic review of methods applied to disinfect cardiovascular tissues. The use of multiple broad spectrum antibiotics in conjunction with an antifungal agent resulted in the greatest reduction in bioburden. Antibiotic incubation periods were limited to less than 24 h, and most protocols incubated tissues at 4 °C, however one study demonstrated a greater reduction of microbial load at 37 °C. None of the reviewed studies looked at the impact of these disinfection protocols on the risk of infection or any other clinical outcome in recipients. Electronic supplementary material The online version of this article (doi:10.1007/s10561-016-9570-9) contains supplementary material, which is available to authorized users.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Bioburden
Antibiotics
Cell Culture Techniques
Biomedical Engineering
Tissue Banks
030204 cardiovascular system & hematology
Biology
Tissue donation
Tissue decontamination
Biomaterials
03 medical and health sciences
0302 clinical medicine
Tissue Donation
Cardiovascular allografts
Cardiac valve
medicine
Humans
Transplantation, Homologous
Intensive care medicine
Transplantation
Bacteria
Fungi
Sterilization
Structural integrity
Tissue banking
Bacterial Infections
Cell Biology
Sterilization (microbiology)
Allografts
Heart Valves
Anti-Bacterial Agents
Surgery
Full Length Review
Disinfection
Mycoses
Tissue bank
030221 ophthalmology & optometry
Tissue Banking
Subjects
Details
- ISSN :
- 15736814 and 13899333
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Cell and Tissue Banking
- Accession number :
- edsair.doi.dedup.....4d7eed79b49188506a1e3f5ac3c76007