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Nicotine metabolite ratio as a predictor of cigarette consumption
- Source :
- Nicotine & Tobacco Research. 5:621-624
- Publication Year :
- 2003
- Publisher :
- Oxford University Press (OUP), 2003.
-
Abstract
- The rate of nicotine metabolism is hypothesized to be a determinant of how much a person smokes. That is, rapid metabolizers would be expected to need more nicotine and, therefore, smoke more than slow metabolizers. Nicotine is metabolized extensively by the liver enzyme CYP2A6, primarily to cotinine. Cotinine is itself metabolized by CYP2A6 to 3'-hydroxycotinine (3-HC). The ratio of metabolite to parent (i.e., 3-HC:cotinine) would be expected to reflect CYP2A6 activity. We measured the ratio of 3-HC:cotinine in the urine of 72 smokers. This ratio was significantly correlated with the number of cigarettes smoked per day (r=.33, p=.005), though not with the Fagerström Test for Nicotine Dependence. This finding supports the hypothesis that the rate of nicotine metabolism is a determinant of the level of cigarette consumption and supports the use of the 3-HC:cotinine ratio as a noninvasive marker of nicotine metabolism.
- Subjects :
- Adult
Male
Fagerstrom Test for Nicotine Dependence
Nicotine
medicine.medical_specialty
Metabolite
Urine
Sensitivity and Specificity
chemistry.chemical_compound
Predictive Value of Tests
Liver enzyme
Internal medicine
medicine
Humans
Cotinine
CYP2A6
Smoke
Chemistry
Smoking
Public Health, Environmental and Occupational Health
Tobacco Use Disorder
Middle Aged
Ganglionic Stimulants
Endocrinology
Biochemistry
Female
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 1469994X and 14622203
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Nicotine & Tobacco Research
- Accession number :
- edsair.doi.dedup.....4d7d9b28c9823a9c65abc23955600e3f