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Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma
Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma
- Source :
- Cellular and molecular life sciences : CMLS. 64(2)
- Publication Year :
- 2006
-
Abstract
- Autotaxin is a secreted cell motility-stimulating exo-phosphodiesterase with lysophospholipase D activity that generates bioactive lysophosphatidic acid. Lysophosphatidic acid has been implicated in various neural cell functions such as neurite remodeling, demyelination, survival and inhibition of axon growth. Here, we report on the in vivo expression of autotaxin in the brain during development and following neurotrauma. We found that autotaxin is expressed in the proliferating subventricular and choroid plexus epithelium during embryonic development. After birth, autotaxin is mainly found in white matter areas in the central nervous system. In the adult brain, autotaxin is solely expressed in leptomeningeal cells and oligodendrocyte precursor cells. Following neurotrauma, autotaxin is strongly up-regulated in reactive astrocytes adjacent to the lesion. The present study revealed the cellular distribution of autotaxin in the developing and lesioned brain and implies a function of autotaxin in oligodendrocyte precursor cells and brain injuries.
- Subjects :
- Male
Neurite
Central nervous system
Cell
Fluorescent Antibody Technique
In situ hybridization
Biology
Gene Expression Regulation, Enzymologic
Rats, Sprague-Dawley
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Lysophosphatidic acid
Chlorocebus aethiops
medicine
Animals
Pyrophosphatases
Molecular Biology
In Situ Hybridization
DNA Primers
Pharmacology
Phosphoric Diester Hydrolases
Reverse Transcriptase Polymerase Chain Reaction
Brain
Gene Expression Regulation, Developmental
Cell Biology
Immunohistochemistry
Cell biology
Rats
medicine.anatomical_structure
Biochemistry
chemistry
Brain Injuries
COS Cells
Molecular Medicine
Neuroglia
lipids (amino acids, peptides, and proteins)
Female
Signal transduction
Autotaxin
Lysophospholipids
Signal Transduction
Subjects
Details
- ISSN :
- 1420682X
- Volume :
- 64
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cellular and molecular life sciences : CMLS
- Accession number :
- edsair.doi.dedup.....4d6eec1166c568b2ca9f3af1226fc103