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Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma

Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma

Authors :
Junken Aoki
Mark R. N. Kotter
L. Rocha
Gert Lubec
Alexandra S. Baer
Nicolai E. Savaskan
Yasuhiro Kishi
L. A. van Meeteren
Robert Nitsch
Anja U. Bräuer
Wouter H. Moolenaar
Source :
Cellular and molecular life sciences : CMLS. 64(2)
Publication Year :
2006

Abstract

Autotaxin is a secreted cell motility-stimulating exo-phosphodiesterase with lysophospholipase D activity that generates bioactive lysophosphatidic acid. Lysophosphatidic acid has been implicated in various neural cell functions such as neurite remodeling, demyelination, survival and inhibition of axon growth. Here, we report on the in vivo expression of autotaxin in the brain during development and following neurotrauma. We found that autotaxin is expressed in the proliferating subventricular and choroid plexus epithelium during embryonic development. After birth, autotaxin is mainly found in white matter areas in the central nervous system. In the adult brain, autotaxin is solely expressed in leptomeningeal cells and oligodendrocyte precursor cells. Following neurotrauma, autotaxin is strongly up-regulated in reactive astrocytes adjacent to the lesion. The present study revealed the cellular distribution of autotaxin in the developing and lesioned brain and implies a function of autotaxin in oligodendrocyte precursor cells and brain injuries.

Details

ISSN :
1420682X
Volume :
64
Issue :
2
Database :
OpenAIRE
Journal :
Cellular and molecular life sciences : CMLS
Accession number :
edsair.doi.dedup.....4d6eec1166c568b2ca9f3af1226fc103