Back to Search
Start Over
Silyldefluorination of Fluoroarenes by Concerted Nucleophilic Aromatic Substitution
- Source :
- Angewandte Chemie. 131:289-293
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- The reaction of readily generated silyl lithium reagents with various aryl fluorides to provide the corresponding aryl silanes is reported. DFT calculations reveal that the nucleophilic aromatic substitution of the fluoride anion by the silyl lithium reagent proceeds through concerted ipso substitution. In contrast to the classical nucleophilic aromatic substitution, this concerted ionic silyldefluorination also occurs on more electron-rich aryl fluorides.
- Subjects :
- Reaction mechanism
Silanes
Silylation
Chemistry
010405 organic chemistry
Aryl
chemistry.chemical_element
General Chemistry
General Medicine
Electrophilic aromatic substitution
010402 general chemistry
Medicinal chemistry
01 natural sciences
Catalysis
0104 chemical sciences
chemistry.chemical_compound
Nucleophilic aromatic substitution
Reagent
Lithium
Subjects
Details
- ISSN :
- 00448249
- Volume :
- 131
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie
- Accession number :
- edsair.doi.dedup.....4d6b0631f683515d14db41921668ef4b