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Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination
- Source :
- Breast Cancer Research : BCR
- Publication Year :
- 2014
-
Abstract
- Introduction Traditional factors currently used for prognostic stratification do not always adequately predict treatment response and disease evolution in advanced breast cancer patients. Therefore, the use of blood-based markers, such as circulating tumor cells (CTCs), represents a promising complementary strategy for disease monitoring. In this retrospective study, we explored the role of CTC counts as predictors of disease evolution in breast cancer patients with limited metastatic dissemination. Methods A total of 492 advanced breast cancer patients who had a CTC count assessed by CellSearch prior to starting a new line of systemic therapy were eligible for this analysis. Using the threshold of 5 CTCs/7.5 ml of blood, pretreatment CTC counts were correlated in the overall population with metastatic site distribution, evaluated at baseline and at the time of treatment failure, using Fisher’s exact test. Time to visceral progression and time to the development of new metastatic lesions and sites were estimated in patients with nonvisceral metastases and with single-site metastatic disease, respectively, by the Kaplan-Meier method. Survival times were compared between groups according to pretreatment CTC count by logrank test. Results In the overall population, a pretreatment level ≥5 CTCs/7.5 ml was associated with an increased baseline number of metastatic sites compared with
- Subjects :
- Oncology
medicine.medical_specialty
Prognosi
Population
Bone Neoplasms
Breast Neoplasms
Kaplan-Meier Estimate
Bone Neoplasm
Disease-Free Survival
Breast cancer
Circulating tumor cell
Internal medicine
medicine
Humans
education
Proportional Hazards Models
Medicine(all)
education.field_of_study
business.industry
Cancer
Bone metastasis
Lymphatic Metastasi
medicine.disease
Prognosis
Neoplastic Cells, Circulating
Log-rank test
Exact test
Lymphatic Metastasis
Disease Progression
Female
business
Breast Neoplasm
Brain metastasis
Research Article
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research : BCR
- Accession number :
- edsair.doi.dedup.....4d648044cfe80c940bd377eb0eec5732