Back to Search
Start Over
Zika-Induced Male Infertility in Mice Is Potentially Reversible and Preventable by Deoxyribonucleic Acid Immunization
- Source :
- The Journal of Infectious Diseases. 219:365-374
- Publication Year :
- 2018
- Publisher :
- Oxford University Press (OUP), 2018.
-
Abstract
- BACKGROUND: Zika virus (ZIKV) infection has been associated with prolonged viral excretion in human semen and causes testicular atrophy and infertility in 10-week-old immunodeficient mice. METHODS: Male IFNAR(−/−) mice, knockout for type I interferon receptor, were immunized with GLS-5700, a deoxyribonucleic acid-based vaccine, before a subcutaneous ZIKV challenge with 6 × 10(5) plaque-forming units at 13 weeks of age. On day 28 postinfection, testes and epididymides were collected in some mice for histological and functional analyses, whereas others were mated with naive female wild-type C57BL/6J. RESULTS: Although all mice challenged with ZIKV developed viremia, most of them were asymptomatic, showed no weight loss, and survived infection. On day 28 postinfection, none of the unvaccinated, infected mice (9 of 9) exhibited abnormal spermatozoa counts or motility. However, 33% (3 of 9) and 36% (4 of 11) of mated males from this group were infertile, from 2 independent studies. Contrarily, males from the noninfected and the vaccinated, infected groups were all fertile. On days 75 and 207 postinfection, partial recovery of fertility was observed in 66% (2 of 3) of the previously infertile males. CONCLUSIONS: This study reports the effects of ZIKV infection on male fertility in a sublethal, immunodeficient mouse model and the efficacy of GLS-5700 vaccination in preventing male infertility.
- Subjects :
- Male
0301 basic medicine
Infertility
Physiology
Semen
Viremia
Mice, SCID
Receptor, Interferon alpha-beta
Asymptomatic
Male infertility
Zika virus
Major Articles and Brief Reports
Mice
Sexual Behavior, Animal
03 medical and health sciences
0302 clinical medicine
Testis
medicine
Animals
Immunology and Allergy
030212 general & internal medicine
Infertility, Male
Epididymis
Mice, Knockout
Sperm Count
biology
Testicular atrophy
Zika Virus Infection
business.industry
Vaccination
DNA
medicine.disease
biology.organism_classification
Spermatozoa
3. Good health
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
Infectious Diseases
Sperm Motility
Female
Immunization
Atrophy
medicine.symptom
business
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 219
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....4d643f9219f63fb59d21cc4aab1424fc