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Transient hepatic fibrin-ring granulomas in a patient with acute hepatitis A
- Source :
- Liver. 15:276-279
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- A case of acute hepatitis A associated with fibrin-ring granulomas in the liver is presented. Because a relationship between acute hepatitis A infection and granuloma formation had not previously been established, liver specimens were examined from both the hepatitic and recovery phases. Numerous fibrin-ring granulomas were observed in the parenchyma during the hepatitic phase. The cellular components of the granulomas were largely macrophages and CD4-positive T-cells. Granulomas had disappeared completely by the recovery phase. These results suggest that fibrin-ring granulomas were caused by hepatitis A virus infection. This virus may activate macrophages and CD4-positive T-cells through an as-yet undetermined mechanism.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Fibrin ring granuloma
Fibrin
Virus
hemic and lymphatic diseases
Parenchyma
medicine
Humans
Granuloma
Hepatology
biology
business.industry
Liver Diseases
Hepatitis A
medicine.disease
Acute Disease
Immunology
biology.protein
Viral disease
business
Recovery phase
Acute hepatitis
Subjects
Details
- ISSN :
- 01069543
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Liver
- Accession number :
- edsair.doi.dedup.....4d5af4872991090b9f3da0b1d1244771