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STIMULATED MICROGLIA SUPERNATANTS INDUCED OVEREXPRESSION OF NEURONAL NITRIC OXIDE GENE IN ASTROCYTES
- Source :
- International Journal of Neuroscience. 113:1069-1079
- Publication Year :
- 2003
- Publisher :
- Informa UK Limited, 2003.
-
Abstract
- The glia-glia, glia-neuron interactions are very complex and have not yet been clearly understood. Microglia gain reactivity in almost every type of brain insult and by affecting astrocytes and neurons, they determine the fate of damaged brain. In the present study we aimed to see the effect of stimulated microglia on nNOS and iNOS expression of astrocytes. The microglia cultures were stimulated with zymosanA and astrocytes were treated with the medium of microglia for 48 h. The results revealed that the astrocytes treated with microglia medium expressed more nNOS and iNOS than the ones treated with normal medium.
- Subjects :
- Nitric Oxide Synthase Type I
Cell-free system
Rats, Sprague-Dawley
Gene expression
medicine
Animals
Cells, Cultured
Neurons
chemistry.chemical_classification
Cell-Free System
Microglia
biology
Chemistry
General Neuroscience
General Medicine
Rats
Cell biology
Nitric oxide synthase
medicine.anatomical_structure
Enzyme
nervous system
Cell culture
Astrocytes
Culture Media, Conditioned
biology.protein
Neuroglia
Nitric Oxide Synthase
Neuroscience
Astrocyte
Subjects
Details
- ISSN :
- 15435245 and 00207454
- Volume :
- 113
- Database :
- OpenAIRE
- Journal :
- International Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....4d59c1819f170bbb13842b67dfdf9f13