Back to Search
Start Over
N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 17:4432-4436
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity.
- Subjects :
- Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Mice, Transgenic
Biochemistry
Chemical synthesis
Mice
chemistry.chemical_compound
In vivo
Drug Discovery
Animals
Hydroxymethyl
Molecular Biology
Alkyl
chemistry.chemical_classification
Sulfonamides
Amyloid beta-Peptides
Molecular Structure
biology
Chemistry
Organic Chemistry
Brain
Biological activity
Sulfonamide
Enzyme inhibitor
biology.protein
Molecular Medicine
Amyloid Precursor Protein Secretases
Amyloid precursor protein secretase
Protein Binding
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....4d4e4c718d573bc4fecf0106868fda33
- Full Text :
- https://doi.org/10.1016/j.bmcl.2007.06.022