Back to Search
Start Over
Survival of atherosclerotic patients as related to oxidative stress and gene polymorphisms
- Source :
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 621:119-128
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- A prospective molecular epidemiology study was implemented in a cohort of 98 subjects suffering from severe atherosclerotic lesions requiring removal of an abdominal aorta fragment. We previously published the results relative to detection, in the aorta medium layer, of bulky DNA adducts and fluorescent polycyclic aromatic hydrocarbon-related DNA adducts, oxidative DNA damage, and mitochondrial DNA 4977 common deletion, as well as GSTM1 and GSTT1 gene polymorphisms. We report herein new data, relative to oxidative stress biomarkers, including oxidative DNA damage in both inner and medium aorta layers, malondialdehyde in the medium layer, homocysteine and reduced glutathione in plasma, and those relative to additional gene polymorphisms, including NAT1, NAT2, OGG1, MTHFR, Leiden factor V, and prothrombin. The results of biochemical and molecular analyses were related to survival of the patients, whose average age was 70 at the start of the follow up. During the following 14 years, 71.4% of them died. The results obtained provide evidence for the crucial impact of oxidative stress and certain gene polymorphisms on clinical and biochemical patterns as well as on survival of patients. Survival was significantly affected not only by traditional risk factors for atherosclerosis but also by molecular end-points and adverse gene polymorphisms, and by their combinations.
- Subjects :
- medicine.medical_specialty
Mitochondrial DNA
Homocysteine
DNA damage
Health, Toxicology and Mutagenesis
Kaplan-Meier Estimate
Biology
medicine.disease_cause
chemistry.chemical_compound
Internal medicine
Genetics
medicine
Humans
Prospective Studies
Molecular Biology
Gene
Atherosclerosis
Malondialdehyde
Glutathione
Molecular biology
Oxidative Stress
Endocrinology
chemistry
Methylenetetrahydrofolate reductase
biology.protein
Restriction fragment length polymorphism
Biomarkers
Polymorphism, Restriction Fragment Length
Oxidative stress
DNA Damage
Follow-Up Studies
Subjects
Details
- ISSN :
- 00275107
- Volume :
- 621
- Database :
- OpenAIRE
- Journal :
- Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- Accession number :
- edsair.doi.dedup.....4d2e04ebeb96691bf8e3512fc00e5494