Back to Search
Start Over
A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function
- Source :
- Bioorganic & Medicinal Chemistry Letters. 16:718-721
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.
- Subjects :
- Niacinamide
Phosphodiesterase Inhibitors
Clinical Biochemistry
Pharmaceutical Science
Biochemistry
Isozyme
chemistry.chemical_compound
Drug Discovery
Leukocytes
medicine
Molecular Biology
Rolipram
chemistry.chemical_classification
Nicotinamide
Chemotaxis
Organic Chemistry
respiratory system
Eosinophil
Cyclic Nucleotide Phosphodiesterases, Type 4
Eosinophils
Isoenzymes
Enzyme
medicine.anatomical_structure
chemistry
Mechanism of action
3',5'-Cyclic-AMP Phosphodiesterases
Molecular Medicine
medicine.symptom
Function (biology)
medicine.drug
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....4d23e0f0dd362554a78f820bb3c0f7b6
- Full Text :
- https://doi.org/10.1016/j.bmcl.2005.10.026