Back to Search
Start Over
Erythrocyte omega-3 index, ambient fine particle exposure, and brain aging
- Source :
- Neurology
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- ObjectiveTo examine whether long-chain omega-3 polyunsaturated fatty acid (LCn3PUFA) levels modify the potential neurotoxic effects of particle matter with diameters 2.5) exposure on normal-appearing brain volumes among dementia-free elderly women.MethodsA total of 1,315 women (age 65–80 years) free of dementia were enrolled in an observational study between 1996 and 1999 and underwent structural brain MRI in 2005 to 2006. According to prospectively collected and geocoded participant addresses, we used a spatiotemporal model to estimate the 3-year average PM2.5 exposure before the MRI. We examined the joint associations of baseline LCn3PUFAs in red blood cells (RBCs) and PM2.5 exposure with brain volumes in generalized linear models.ResultsAfter adjustment for potential confounders, participants with higher levels of RBC LCn3PUFA had significantly greater volumes of white matter and hippocampus. For each interquartile increment (2.02%) in omega-3 index, the average volume was 5.03 cm3 (p < 0.01) greater in the white matter and 0.08 cm3 (p = 0.03) greater in the hippocampus. The associations with RBC docosahexaenoic acid and eicosapentaenoic acid levels were similar. Higher LCn3PUFA attenuated the inverse associations between PM2.5 exposure and white matter volumes in the total brain and multimodal association areas (frontal, parietal, and temporal; all p for interaction ConclusionsFindings from this prospective cohort study among elderly women suggest that the benefits of LCn3PUFAs on brain aging may include the protection against potential adverse effects of air pollution on white matter volumes.
- Subjects :
- 0301 basic medicine
Erythrocytes
Physiology
Article
Cohort Studies
Healthy Aging
White matter
03 medical and health sciences
0302 clinical medicine
Fatty Acids, Omega-3
Humans
Medicine
Dementia
Prospective Studies
Prospective cohort study
Adverse effect
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Confounding
Brain
Magnetic resonance imaging
Environmental Exposure
medicine.disease
Magnetic Resonance Imaging
030104 developmental biology
medicine.anatomical_structure
Female
Particulate Matter
Observational study
Neurology (clinical)
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....4d1d35ce3ddaf1f1d2d84bb2c29bed47