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Technique and preliminary findings for in vivo quantification of brain motion during injurious head impacts
- Source :
- Journal of biomechanics. 95
- Publication Year :
- 2019
-
Abstract
- Computational models of the human brain are widely used in the evaluation and development of helmets and other protective equipment. These models are often attempted to be validated using cadaver tissue displacements despite studies showing neural tissue degrades quickly after death. Addressing this limitation, this study aimed to develop a technique for quantifying living brain motion in vivo using a closed head impact animal model of traumatic brain injury (TBI) called CHIMERA. We implanted radiopaque markers within the brain of three adult ferrets and resealed the skull while the animals were anesthetized. We affixed additional markers to the skull to track skull kinematics. The CHIMERA device delivered controlled, repeatable head impacts to the head of the animals while the impacts were fluoroscopically stereo-visualized. We observed that 1.5 mm stainless steel fiducials (∼8 times the density of the brain) migrated from their implanted positions while neutral density targets remained in their implanted position post-impact. Brain motion relative to the skull was quantified in neutral density target tests and showed increasing relative motion at higher head impact severities. We observed the motion of the brain lagged behind that of the skull, similar to previous studies. This technique can be used to obtain a comprehensive dataset of in vivo brain motion to validate computational models reflecting the mechanical properties of the living brain. The technique would also allow the mechanical response of in vivo brain tissue to be compared to cadaveric preparations for investigating the fidelity of current human computational brain models.
- Subjects :
- Traumatic brain injury
0206 medical engineering
Biomedical Engineering
Biophysics
02 engineering and technology
Kinematics
Radiostereometric Analysis
03 medical and health sciences
Motion
0302 clinical medicine
In vivo
Cadaver
Brain Injuries, Traumatic
medicine
Image Processing, Computer-Assisted
Animals
Humans
Orthopedics and Sports Medicine
Computer Simulation
business.industry
Rehabilitation
Skull
Ferrets
Brain
Human brain
medicine.disease
020601 biomedical engineering
Biomechanical Phenomena
Disease Models, Animal
medicine.anatomical_structure
Head Protective Devices
business
Cadaveric spasm
Fiducial marker
Head
030217 neurology & neurosurgery
Biomedical engineering
Subjects
Details
- ISSN :
- 18732380
- Volume :
- 95
- Database :
- OpenAIRE
- Journal :
- Journal of biomechanics
- Accession number :
- edsair.doi.dedup.....4d15e9bcacc64742819b8d6dd746d06a