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Is systemic inflammation of hemodialysis patients improved with the use of enalapril? Results of a randomized, double-blinded, placebo-controlled clinical trial
- Source :
- ASAIO journal (American Society for Artificial Internal Organs : 1992). 56(1)
- Publication Year :
- 2010
-
Abstract
- This study compared the effect of enalapril versus placebo on serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and C-reactive protein (CRP) in hemodialysis in a randomized, double- blinded, controlled clinical trial. Patients without infection or antiinflammatory drugs were randomly allocated to a study (n = 13, enalapril, 20 mg/day) or control (n = 12, placebo) group; all had arteriovenous fistula. Serum TNF-alpha, IL-6, and CRP were measured at 0, 1, and 3 months. Systolic blood pressure (baseline vs. final) was 151 +/- 25 vs. 135 +/- 19 mm Hg (p < 0.05) in the study group and 154 +/- 21 vs. 144 +/- 27 mm Hg in control group; diastolic blood pressure was 86 +/- 9 vs. 76 +/- 13 and 91 +/- 16 vs. 81 +/- 18 mm Hg, respectively; median (percentiles 25%-75%) IL-6 (baseline vs. final) was 4.2 (3-8) vs. 4.1 (2-9) pg/mL and 6.3 (3-9) vs. 6.7 (3-8) pg/mL; and CRP was 1.9 (1-7) vs. 3.0 (1-12) mg/L and 4.7 (1-16) vs. 3.9 (2-16) mg/L, respectively. TNF-alpha was detected in only two patients. Enalapril significantly reduced blood pressure in hemodialysis patients, but it did not decrease IL-6 and CRP compared with placebo.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Biomedical Engineering
Biophysics
Arteriovenous fistula
Bioengineering
Angiotensin-Converting Enzyme Inhibitors
Placebo
Gastroenterology
Biomaterials
Double-Blind Method
Enalapril
Renal Dialysis
Internal medicine
Medicine
Humans
Inflammation
biology
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
C-reactive protein
Interleukin
General Medicine
medicine.disease
Clinical trial
Blood pressure
C-Reactive Protein
Physical therapy
biology.protein
Kidney Failure, Chronic
Female
Hemodialysis
business
medicine.drug
Subjects
Details
- ISSN :
- 1538943X
- Volume :
- 56
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- ASAIO journal (American Society for Artificial Internal Organs : 1992)
- Accession number :
- edsair.doi.dedup.....4d1537550a4872166d321efab2e84ccd