Back to Search
Start Over
Adult Living Donor Liver Transplantation Using Hepatitis B Core Antibody-Positive Grafts in Korea, a Hepatitis B-endemic Region
- Source :
- Gut and Liver
- Publication Year :
- 2011
- Publisher :
- The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Society of Pancreatobiliary Diseases, 2011.
-
Abstract
- Background/Aims The exclusion of hepatitis B core antibody (HBcAb)-positive donors from liver transplants (LTs) due to the risk of transmitting hepatitis B virus (HBV) does not appear to be practical in Korea, where hepatitis B is endemic. This study assessed the risk of de novo HBV infection in hepatitis B surface antigen (HBsAg)-negative LT recipients receiving a liver from HBcAb-positive donors. Methods Of 341 adult living donor LTs conducted at our institution between March 2001 and September 2008, 176 donors (51.6%) were HBcAb-positive, and 26 HBcAb-positive grafts were transplanted to HBsAg-negative recipients. The median follow-up time after LT was 41.9 months. Results Without anti-HBV prophylaxis, 2 out of 26 (7.7%) HBsAg-negative recipients who received grafts from HBcAb-positive donors developed de novo HBV infection 20 and 85 months after LT. These patients had been negative for all HBV serologic markers before transplantation. In both cases, there were no abnormalities in liver function tests upon diagnosis of de novo HBV infection. Conclusions De novo HBV infection from HBcAb-positive donors after LT does not appear to be of great concern in terms of the number of cases in Korea because high risk patients who are HBV-negative comprise only a small proportion of the recipients. However, HBV-naïve LT recipients still carry the risk of developing de novo HBV infection as in non-HBV endemic areas.
- Subjects :
- Hepatitis B virus
HBsAg
Liver transplantation
Hepatology
business.industry
medicine.medical_treatment
Liver, Pancreas and Biliary Tract
Hepatitis B core antibody
Gastroenterology
virus diseases
Hepatitis B
Hepatitis b surface antigen
medicine.disease
medicine.disease_cause
Virology
Hepatitis b core antibody
digestive system diseases
Immunology
medicine
HEPATITIS B CORE ANTIBODY POSITIVE
Original Article
Living donor liver transplantation
business
De novo hepatitis
Subjects
Details
- Language :
- English
- ISSN :
- 20051212 and 19762283
- Volume :
- 5
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Gut and Liver
- Accession number :
- edsair.doi.dedup.....4cfbf92ed57c464cd6c5dfcf15976845