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The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients

Authors :
Jill P. Buyon
Daniel J. Wallace
Marvin J. Fritzler
Murray B. Urowitz
Paul R. Fortin
Munther A. Khamashta
Ian N. Bruce
Sasha Bernatsky
M. Petri
Diane L. Kamen
Anca Askanase
Søren Jacobsen
Sang Cheol Bae
Y. St. Pierre
Mary Anne Dooley
Cynthia Aranow
Kristjan Steinsson
May Y. Choi
Anisur Rahman
John G. Hanly
Jorge Sanchez-Guerrero
Christine A. Peschken
Graciela S. Alarcón
Michael Mahler
S. Sam Lim
J. Romero-Diaz
Murat Inanc
Asad Zoma
R. van Vollenhoven
Caroline Gordon
Dafna D. Gladman
Ellen M. Ginzler
Guillermo Ruiz-Irastorza
Ola Nived
Susan Manzi
Rosalind Ramsey-Goldman
Ann E. Clarke
David A. Isenberg
Joan T. Merrill
Kenneth C. Kalunian
Manuel Ramos-Casals
AII - Inflammatory diseases
Rheumatology
Clinical Immunology and Rheumatology
AMS - Amsterdam Movement Sciences
AII - Amsterdam institute for Infection and Immunity
Source :
Choi, M Y, Clarke, A E, St Pierre, Y, Hanly, J G, Urowitz, M B, Romero-Diaz, J, Gordon, C, Bae, S C, Bernatsky, S, Wallace, D J, Merrill, J T, Isenberg, D A, Rahman, A, Ginzler, E M, Petri, M, Bruce, I N, Dooley, M A, Fortin, P, Gladman, D D, Sanchez-Guerrero, J, Steinsson, K, Ramsey-Goldman, R, Khamashta, M A, Aranow, C, Alarcón, G S, Manzi, S, Nived, O, Zoma, A A, Van Vollenhoven, R F, Ramos-Casals, M, Ruiz-Irastorza, G, Lim, S S, Kalunian, K C, Inanc, M, Kamen, D L, Peschken, C A, Jacobsen, S, Askanase, A, Buyon, J, Mahler, M & Fritzler, M J 2017, ' The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients ', Lupus, vol. 26, no. 10, pp. 1051-1059 . https://doi.org/10.1177/0961203317692437, Lupus, 26(10), 1051-1059. SAGE Publications Ltd
Publication Year :
2017

Abstract

Autoantibodies to dense fine speckles 70 (DFS70) are purported to rule out the diagnosis of SLE when they occur in the absence of other SLE-related autoantibodies. This study is the first to report the prevalence of anti-DFS70 in an early, multinational inception SLE cohort and examine demographic, clinical, and autoantibody associations. Patients were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. The association between anti-DFS70 and multiple parameters in 1137 patients was assessed using univariate and multivariate logistic regression. The frequency of anti-DFS70 was 7.1% (95% CI: 5.7–8.8%), while only 1.1% (95% CI: 0.6–1.9%) were monospecific for anti-DFS70. In multivariate analysis, patients with musculoskeletal activity (Odds Ratio (OR) 1.24 [95% CI: 1.10, 1.41]) or with anti-β2 glycoprotein 1 (OR 2.17 [95% CI: 1.22, 3.87]) were more likely and patients with anti-dsDNA (OR 0.53 [95% CI: 0.31, 0.92]) or anti-SSB/La (OR 0.25 [95% CI: 0.08, 0.81]) were less likely to have anti-DFS70. In this study, the prevalence of anti-DFS70 was higher than the range previously published for adult SLE (7.1 versus 0–2.8%) and was associated with musculoskeletal activity and anti-β2 glycoprotein 1 autoantibodies. However, ‘monospecific’ anti-DFS70 autoantibodies were rare (1.1%) and therefore may be helpful to discriminate between ANA-positive healthy individuals and SLE.

Details

Language :
English
ISSN :
09612033
Database :
OpenAIRE
Journal :
Choi, M Y, Clarke, A E, St Pierre, Y, Hanly, J G, Urowitz, M B, Romero-Diaz, J, Gordon, C, Bae, S C, Bernatsky, S, Wallace, D J, Merrill, J T, Isenberg, D A, Rahman, A, Ginzler, E M, Petri, M, Bruce, I N, Dooley, M A, Fortin, P, Gladman, D D, Sanchez-Guerrero, J, Steinsson, K, Ramsey-Goldman, R, Khamashta, M A, Aranow, C, Alarcón, G S, Manzi, S, Nived, O, Zoma, A A, Van Vollenhoven, R F, Ramos-Casals, M, Ruiz-Irastorza, G, Lim, S S, Kalunian, K C, Inanc, M, Kamen, D L, Peschken, C A, Jacobsen, S, Askanase, A, Buyon, J, Mahler, M & Fritzler, M J 2017, ' The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients ', Lupus, vol. 26, no. 10, pp. 1051-1059 . https://doi.org/10.1177/0961203317692437, Lupus, 26(10), 1051-1059. SAGE Publications Ltd
Accession number :
edsair.doi.dedup.....4cfb6534cbcc6b8c6e512f2f25cd4164
Full Text :
https://doi.org/10.1177/0961203317692437