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Ovarian toxicity of paclitaxel and effect on fertility in the rat
- Source :
- The journal of obstetrics and gynaecology research. 35(3)
- Publication Year :
- 2009
-
Abstract
- Aim: Taxanes are regarded as key chemotherapy agents for breast cancer and gynecologic malignancies; therefore the ovarian toxicity of paclitaxel (PTX) is a matter of importance to younger women with malignancies. We examined the ovarian toxicity of PTX and its influence on fertility in rats. Methods: Female Wistar rats aged 6–8 weeks received five doses of PTX at 3-day intervals. Ovarian toxicity was assessed by counting follicles, corpora lutea and atretic follicles, as well as by detecting apoptosis and measuring serum levels of estradiol (E2) and progesterone (P4). Fertility was assessed by mating females immediately or 24 days after PTX treatment. The number of fetuses, implantations and resorption sites was counted in each group. Results: Exposure to PTX caused a decrease of antral follicles, but not primordial or pre-antral follicles. The number of corpora lutea showed a significant decrease, while follicular atresia was increased significantly. Apoptosis was only detected in antral follicles. Serum E2 levels were lower than in control rats, but not significantly, while P4 levels did not differ from those in control rats. Rats mated immediately after PTX treatment showed a significant decrease of fetuses and implantations, but these effects were not detected in rats mated at 24 days after treatment. Conclusion: Our findings suggest that the ovarian toxicity of PTX is mild and transient. Use of PTX may help to maintain the fertility of younger women because the fertility of rats was not influenced at 24 days after exposure to this drug.
- Subjects :
- endocrine system
medicine.medical_specialty
Paclitaxel
media_common.quotation_subject
medicine.medical_treatment
Fertility
Apoptosis
chemistry.chemical_compound
Ovarian Follicle
Corpus Luteum
Pregnancy
Internal medicine
medicine
Animals
Rats, Wistar
Progesterone
media_common
Fetus
Chemotherapy
Estradiol
business.industry
Follicular atresia
Ovary
Obstetrics and Gynecology
Antral follicle
Antineoplastic Agents, Phytogenic
Resorption
Rats
Endocrinology
chemistry
Female
business
Subjects
Details
- ISSN :
- 13418076
- Volume :
- 35
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The journal of obstetrics and gynaecology research
- Accession number :
- edsair.doi.dedup.....4cf3b3cc2fc0e9fbc45897c9fc38bf8d