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Antipsychotics preserve telomere length in peripheral blood mononuclear cells after acute oxidative stress injury
- Source :
- Neural Regeneration Research, Vol 17, Iss 5, Pp 1156-1160 (2022), Neural Regeneration Research
- Publication Year :
- 2022
- Publisher :
- Wolters Kluwer Medknow Publications, 2022.
-
Abstract
- Antipsychotics may prolong or retain telomere length, affect mitochondrial function, and then affect the metabolism of nerve cells. To validate the hypothesis that antipsychotics can prolong telomere length after oxidative stress injury, leukocytes from healthy volunteers were extracted using Ficoll-Histopaque density gradient. The mononuclear cells layer was resuspended in cell culture medium. Oxidative stress was induced with hydrogen peroxide in cultured leukocytes. Four days later, leukocytes were treated with aripiprazole, haloperidol or clozapine for 7 days. Real-time PCR revealed that treatments with aripiprazole and haloperidol increased the telomere length by 23% and 20% in peripheral blood mononuclear cells after acute oxidative stress injury. These results suggest that haloperidol and aripiprazole can reduce the damage to telomeres induced by oxidative stress. The experiment procedure was approved by the Ethics Committee of Faculty of Medicine of the University of São Paulo (FMUSP/CAAE approval No. 52622616.8.0000.0065).
- Subjects :
- peripheral blood mononuclear cell
medicine.medical_treatment
Pharmacology
medicine.disease_cause
Peripheral blood mononuclear cell
haloperidol
aripiprazole
Developmental Neuroscience
telomere length
Haloperidol
oxidative stress
Medicine
Antipsychotic
RC346-429
Clozapine
cell culture
clozapine
business.industry
antipsychotic
Telomere
Cell culture
Aripiprazole
Neurology. Diseases of the nervous system
business
Oxidative stress
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 16735374
- Volume :
- 17
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Neural Regeneration Research
- Accession number :
- edsair.doi.dedup.....4ce837200b6458a077f1935d1446c98a