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Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes
- Source :
- BMC Infectious Diseases, BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-5 (2018)
- Publication Year :
- 2018
- Publisher :
- BioMed Central, 2018.
-
Abstract
- Background The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions have shown that different pathways are activated during the course of reactions, which is consistent with the exacerbated immune response exhibited by these patients. Methods We used qPCR to screen a panel of 90 genes related to the immune response in leprosy in RNA-derived peripheral leukocytes of patients with (N = 94) and without leprosy reactions (N = 57) in order to define expression signatures correlated to RR or ENL. Results Our results show that there is a marked signature for RR in the blood, comprising genes mostly related to the innate immune responses, including type I IFN components, autophagy, parkins and Toll like receptors. On the other hand, only Parkin was differentially expressed in the ENL group. Conclusions The data put together corroborates previous work that brings evidence that an acute uncontrolled exacerbated immune response designed to contain the spread of M. leprae antigens might be cause of RR pathogenesis. Identifying a blood profile useful to predict leprosy reactions prior to its development might help to reduce the morbidity associated to this disabling disease.
- Subjects :
- 0301 basic medicine
Adult
Male
OASL
Leprosy reactions
gene expression
profile
Disease
Pro-inflammatory
Real-Time Polymerase Chain Reaction
Parkin
lcsh:Infectious and parasitic diseases
Pathogenesis
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Immune system
Antigen
Leprosy
Leukocytes
Medicine
Humans
lcsh:RC109-216
Whole blood
Innate immune system
business.industry
Gene Expression Profiling
Middle Aged
medicine.disease
Immunity, Innate
Mycobacterium leprae
030104 developmental biology
Infectious Diseases
Type-I IFN
Case-Control Studies
Immunology
Female
business
Blood Chemical Analysis
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712334
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- BMC Infectious Diseases
- Accession number :
- edsair.doi.dedup.....4cd7bb93f4756358b7cf24ca4e1808a5