Back to Search
Start Over
Chitosan nanoparticles as a promising candidate for liver injury induced by 2-nitropropane: Implications of P53, iNOS, VEGF, PCNA, and CD68 pathways
- Source :
- Science Progress. 104:003685042110118
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- The current article was designed to assess the role of chitosan nanoparticles (CNPs) in the management of hepatic injury induced by the hepatocarcinogen 2-nitropropane (2-NP). Rats were divided into three groups. The first group served as a control, the second group was injected with 2-NP, while the third group was treated with CNPs 1 h before 2-NP injection every other day for 4 weeks. The 2-NP injection upregulated serum AST and ALT activities, as well as hepatic TNF- α, IL-6, and MDA levels and the expression of vascular endothelial growth factor (VEGF) and caspase-3, whereas GSH contents and SOD activity were decreased. Immunohistochemistry investigations revealed that the hepatic protein expression of collagen I, inducible nitric oxide synthetase, proliferating cell nuclear antigen, cluster of differentiation, and p53 were upregulated. hematoxylin and eosin (H&E) and Masson’s trichrome stains supported the previous parameters, and CNPs ameliorated most of the previous biochemical parameters. CNPs achieved promising results in the limitation of 2-NP hepatotoxicity.
- Subjects :
- Vascular Endothelial Growth Factor A
Collagen i
VEGF receptors
Antigens, Differentiation, Myelomonocytic
Nitroparaffins
Propane
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Antigens, CD
Proliferating Cell Nuclear Antigen
medicine
Animals
030304 developmental biology
Liver injury
Chitosan
0303 health sciences
Multidisciplinary
biology
Tumor Necrosis Factor-alpha
Chemistry
CD68
Chitosan nanoparticles
medicine.disease
Rats
Proliferating cell nuclear antigen
Liver
030220 oncology & carcinogenesis
2-Nitropropane
biology.protein
Cancer research
Nanoparticles
Tumor Suppressor Protein p53
Subjects
Details
- ISSN :
- 20477163 and 00368504
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Science Progress
- Accession number :
- edsair.doi.dedup.....4cd3cefca17db8fa2d777cc94fc17b6b
- Full Text :
- https://doi.org/10.1177/00368504211011839