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Atypical Parkinsonism Revealing a Late Onset, Rigid and Akinetic Form of Huntington's Disease
- Source :
- Case Reports in Neurological Medicine, Vol 2011 (2011), Case Reports in Neurological Medicine
- Publication Year :
- 2011
- Publisher :
- Hindawi Limited, 2011.
-
Abstract
- Huntington's disease (HD) is a rare hereditary neurodegenerative disorder characterized in over 90 percent of cases by chorea as the presenting motor symptom. We report a 54-year-old male who presented with Parkinsonism as the initial symptom of the disease. Genetic analysis revealed expansion of 40 CAG repeats, and brain MRI showed both severe caudate nuclei and cortical atrophy. Single-photon emission computed tomography (SPECT) imaging of the dopamine transporter showed nigrostriatal pathway degeneration. Here, we also describe his 2 years of clinical followup after ensuing dopaminergic stimulation.
- Subjects :
- Pathology
medicine.medical_specialty
biology
business.industry
Parkinsonism
Dopaminergic
Nigrostriatal pathway
Case Report
Late onset
Chorea
medicine.disease
Bioinformatics
lcsh:RC346-429
medicine.anatomical_structure
Huntington's disease
medicine
biology.protein
medicine.symptom
General Agricultural and Biological Sciences
business
Hereditary Neurodegenerative Disorder
lcsh:Neurology. Diseases of the nervous system
Dopamine transporter
Subjects
Details
- Language :
- English
- ISSN :
- 20906676 and 20906668
- Volume :
- 2011
- Database :
- OpenAIRE
- Journal :
- Case Reports in Neurological Medicine
- Accession number :
- edsair.doi.dedup.....4cbe175030a5fa5f2fda1709ed78bd71