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Predictors of methacholine challenge testing results in subjects without airflow obstruction
- Source :
- Journal of Asthma. 59:2060-2068
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Methacholine challenge testing (MCT) is considered when asthma remains clinically suspected despite normal spirometry. Few studies have attempted to determine the predictive factors of MCT results. We aimed to establish which demographic data, clinical symptoms, pulmonary function testing results, and laboratory values were associated with abnormal MCT (provocation concentration causing a 20% decrease in FEVsub1/sub(PC20) ≤ 16 mg/mL) in subjects without airflow obstruction on spirometry.All patients who completed MCT at Montfort Hospital between January 1supst/sup, 2016 and December 31supst/sup, 2018 were identified. Subjects with a reduced FEVsub1/sub/FVC ratio were excluded. We used Pearson's chi-squared test and point-biserial correlation method to determine which variables had a significant relationship (ip/i lt; 0.05) with MCT results.23.3% of patients who underwent MCT had airflow limitation. In the 1126 subjects with a normal FEVsub1/sub/FVC ratio, PC20 ≤ 16 mg/mL was found in 13.0%. Younger age, female gender, body mass index ≥ 40, and reported wheezing were factors associated with increased probability of airway hyper responsiveness. Lower FEVsub1/sub, significant improvement of the FEVsub1/subpost-bronchodilator, reduced FEF25%-75%, greater FEF25%-75% reversibility, airway resistance measurements above the upper limit of normal, and increased blood eosinophil counts were predictive of abnormal MCT.Only 13.0% of patients referred for MCT had a PC20 ≤ 16 mg/mL when the FEVsub1/sub/FVC ratio was normal, highlighting the need to further define in which individuals this test is truly warranted. Further investigation is required to develop an easy-to-use and validated prediction model in order to better understand patients' pretest probability of abnormal MCT.
- Subjects :
- Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_specialty
Provocation test
Bronchial Provocation Tests
Pulmonary function testing
Pulmonary Disease, Chronic Obstructive
FEV1/FVC ratio
Airway resistance
Internal medicine
medicine
Humans
Immunology and Allergy
Methacholine Chloride
Asthma
medicine.diagnostic_test
business.industry
respiratory system
medicine.disease
Bronchodilator Agents
respiratory tract diseases
Airway Obstruction
Pre- and post-test probability
Pediatrics, Perinatology and Child Health
Cardiology
Female
business
Body mass index
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 15324303 and 02770903
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Journal of Asthma
- Accession number :
- edsair.doi.dedup.....4cbaba870cf02e08f6b36ff64b4dcf2f