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Evidence that endogenous thymosin alpha-1 is present in the rat central nervous system
- Source :
- Neurochemistry international. 35(6)
- Publication Year :
- 1999
-
Abstract
- We have previously reported that administration of Thymosin alpha 1 (T-alpha1) can enhance the level of the Nerve Growth Factor and the distribution of its receptor in the developing Central Nervous System (CNS) of rat. To further explore the role of T-alpha1 and verify its presence in cells of rat CNS, we carried out an immunohistochemical study using a polyclonal antibody against T-alpha1. T-alpha1 immunoreactivity was found mainly in neurons of the hippocampus and spinal cord and in several small cells, resembling glial cells, of specific regions of the brain. Moreover, to study whether cerebral cells were receptive to T-alpha1, we injected iodinated T-alpha1 (125I-T-alpha1) i.c.v.. 125I-T-alpha1 labelled neurons were observed in the hypothalamus and septal nuclei. Our results indicate that specific neuronal populations in the rat CNS are able to express and respond to T-alpha1.
- Subjects :
- Male
Thymalfasin
Neuroimmunomodulation
Central nervous system
Hippocampus
Nerve Tissue Proteins
Biology
Immunoenzyme Techniques
Rats, Sprague-Dawley
Cellular and Molecular Neuroscience
medicine
Animals
Fluorescent Antibody Technique, Indirect
Brain Chemistry
Motor Neurons
Neurons
Dentate gyrus
Immune Sera
Pyramidal Cells
Thymosin
Septal nuclei
Cell Biology
Cell biology
Rats
medicine.anatomical_structure
Nerve growth factor
nervous system
Spinal Cord
Hypothalamus
Dentate Gyrus
Neuroglia
Female
Septal Nuclei
Rabbits
Neuroscience
Subjects
Details
- ISSN :
- 01970186
- Volume :
- 35
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Neurochemistry international
- Accession number :
- edsair.doi.dedup.....4cb6309203f0bcd66770b41a81de0842