Back to Search
Start Over
Red Light-Emitting Water-Soluble Luminescent Iridium-Containing Polynorbornenes: Synthesis, Characterization and Oxygen Sensing Properties in Biological Tissues In Vivo
- Source :
- Molecules, Volume 26, Issue 21, Molecules, Vol 26, Iss 6349, p 6349 (2021)
- Publication Year :
- 2021
-
Abstract
- New water-soluble polynorbornenes P1–P4 containing oligoether, amino acid groups and luminophoric complexes of iridium(III) were synthesized by ring-opening metathesis polymerization. The polymeric products in organic solvents and in water demonstrate intense photoluminescence in the red spectral region. The polymers P1 and P3 with 1-phenylisoquinoline cyclometalating ligands in iridium fragments reveal 4–6 fold higher emission quantum yields in solutions than those of P2 and P4 that contain iridium complexes with 1-(thien-2-yl)isoquinoline cyclometalating ligands. The emission parameters of P1–P4 in degassed solutions essentially differ from those in the aerated solutions showing oxygen-dependent quenching of phosphorescence. Biological testing of P1 and P3 demonstrates that the polymers do not penetrate into live cultured cancer cells and normal skin fibroblasts and do not possess cytotoxicity within the concentrations and time ranges reasonable for biological studies. In vivo, the polymers display longer phosphorescence lifetimes in mouse tumors than in muscle, as measured using phosphorescence lifetime imaging (PLIM), which correlates with tumor hypoxia. Therefore, preliminary evaluation of the synthesized polymers shows their suitability for noninvasive in vivo assessments of oxygen levels in biological tissues.
- Subjects :
- tumor
Photoluminescence
Light
Cell Survival
Polymers
oxygen sensing
Pharmaceutical Science
chemistry.chemical_element
Organic chemistry
Biosensing Techniques
Chemistry Techniques, Synthetic
Photochemistry
Iridium
Article
Analytical Chemistry
chemistry.chemical_compound
Mice
QD241-441
iridium-containing polynorbornenes
Drug Discovery
Animals
Humans
phosphorescence lifetime imaging
Physical and Theoretical Chemistry
Isoquinoline
bioimaging
chemistry.chemical_classification
Quenching (fluorescence)
Luminescent Agents
Molecular Structure
Spectrum Analysis
Polymer
Photochemical Processes
Oxygen
in vivo
chemistry
Polymerization
Chemistry (miscellaneous)
Molecular Medicine
Luminescence
Phosphorescence
Plastics
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 26
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....4cb398f7fe7494baf83d725713734535