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6-[18F]fluoro-L-dopa metabolism in living human brain: a comparison of six analytical methods
- Source :
- Hoshi, H, Kuwabara, H, Léger, G, Cumming, P, Guttman, M & Gjedde, A 1993, ' 6-[18F]fluoro-L-dopa metabolism in living human brain: a comparison of six analytical methods. ', Journal of Cerebral Blood Flow and Metabolism, vol. 13, no. 1, pp. 57-69 ., Scopus-Elsevier, University of Southern Denmark
- Publication Year :
- 1993
-
Abstract
- In 11 normal volunteers and six patients with Parkinson's disease, we compared six different analyses of dopaminergic function with l-3,4-dihydroxy-6-[18F]fluorophenylalanine (FDOPA) and positron emission tomography (PET). The caudate nucleus, putamen, and several reference regions were identified in PET images, using magnetic resonance imaging (MRI). The six analyses included two direct determinations of DOPA decarboxylase activity ( kD3, k*3), the slope–intercept plot based on plasma concentration ( K), two slope–intercept plots based on tissue content ( kr3, ks3), and the striato–occipital ratio [ R( T)]. For all analyses, the difference between two groups of subjects (normal volunteers and patients with Parkinson's disease) was larger in the putamen than in the caudate. For the caudate nucleus, the DOPA decarboxylase activity ( kD3, k*3), tissue slope–intercept plots ( kr3, ks3), and striato–occipital ratio [ R( T)] analyses significantly discriminated between the normal volunteers and the patients with Parkinson's disease ( p < 0.005) [with least significance for k*3( p < 0.05)], while the plasma slope–intercept plot ( K) failed to do so. For the putamen, the values for kD3, k*3, K, kr3, ks3and R( T) of normal volunteers were significantly higher than those of patients ( p < 0.005) [with least significance for K ( p < 0.025)]. Linear correlations were significant between kD3and ks3; kD3and kr3; kD3and R( T); and kD3and k*3, in this order of significance. We found no correlation between kD3and K values in the caudate nucleus.
- Subjects :
- Adult
Levodopa
Fluorine Radioisotopes
Parkinson's disease
Caudate nucleus
Models, Biological
Dopamine
medicine
Humans
medicine.diagnostic_test
Chemistry
business.industry
Putamen
Dopaminergic
Parkinson Disease
Human brain
Middle Aged
medicine.disease
Dihydroxyphenylalanine
medicine.anatomical_structure
Neurology
Positron emission tomography
Neurology (clinical)
Caudate Nucleus
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
medicine.drug
Tomography, Emission-Computed
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Hoshi, H, Kuwabara, H, Léger, G, Cumming, P, Guttman, M & Gjedde, A 1993, ' 6-[18F]fluoro-L-dopa metabolism in living human brain: a comparison of six analytical methods. ', Journal of Cerebral Blood Flow and Metabolism, vol. 13, no. 1, pp. 57-69 ., Scopus-Elsevier, University of Southern Denmark
- Accession number :
- edsair.doi.dedup.....4cb36467b4910d26295c38f6e85dcdd2