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Polyfunctional HIV-specific T cells in Post-Treatment Controllers
- Source :
- AIDS (London, England), AIDS (London, England), 2016, 30 (15), pp.2299--2302. ⟨10.1097/QAD.0000000000001195⟩, AIDS (London, England), 2016, 30 (15), pp.2299--2302. 〈10.1097/QAD.0000000000001195〉
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- International audience; To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality of HIV-specific CD4 and CD8 T cells and the ratios of HIV-specific CD4 T cells per infected cells were similar in post-treatment controllers, continuously early-treated patients and long-term non-progressors Overall early treatment appears to preserve robust HIV-specific CD4 T cells, which might contribute to the posttreatment control of HIV.
- Subjects :
- CD4-Positive T-Lymphocytes
0301 basic medicine
Anti-HIV Agents
Immunology
Human immunodeficiency virus (HIV)
HIV Infections
CD8-Positive T-Lymphocytes
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Secondary Prevention
medicine
[ SDV.IMM ] Life Sciences [q-bio]/Immunology
Humans
Immunology and Allergy
Cytotoxic T cell
030212 general & internal medicine
Secondary prevention
business.industry
virus diseases
3. Good health
030104 developmental biology
Infectious Diseases
[SDV.IMM]Life Sciences [q-bio]/Immunology
Post treatment
business
After treatment
Subjects
Details
- ISSN :
- 02699370
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- AIDS
- Accession number :
- edsair.doi.dedup.....4caf255ed369ec5734cdec13e28d356b
- Full Text :
- https://doi.org/10.1097/qad.0000000000001195