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Discovery of 42 genome-wide significant loci associated with dyslexia
- Source :
- Nature Genetics, 54(11), 1621-1629. Nature Publishing Group, Doust, C, Fontanillas, P, Eising, E, Boomsma, D I, De Zeeuw, E L, Hottenga, J-J, Jansen, P R, Van Bergen, E, Bates, T C, Fisher, S E, Luciano, M & Quantitative Trait Working Group of the GenLang Consortium 2022, ' Discovery of 42 genome-wide significant loci associated with dyslexia ', Nature genetics, vol. 54, no. 11, pp. 1621-1629 . https://doi.org/10.1038/s41588-022-01192-y, Nature Genetics, 54, 1621-1629, Nature Genetics, 54, 11, pp. 1621-1629, Pourcain, B S, Francks, C, Marioni, R E, Zhao, J, Paracchini, S, Talcott, J B, Monaco, A P, Stein, J F, Gruen, J R, Olson, R K, Willcutt, E G, DeFries, J C, Pennington, B F, Smith, S D, Wright, M J, Martin, N G, Auton, A & Bates, T C & Fisher, S E & Luciano, M 2022, ' Discovery of 42 genome-wide significant loci associated with dyslexia ', Nature Genetics, vol. 54, no. 11, pp. 1621-1629 . https://doi.org/10.1038/s41588-022-01192-y, Nature genetics, 54(11), 1621-1629. Nature Publishing Group, Nature Genetics
- Publication Year :
- 2022
-
Abstract
- Funding: EE, GA, BM, BSP, CF and SEF are supported by the Max Planck Society (Germany). The Chinese Reading Study was supported by grants from the National Natural Science Foundation of China Youth Project (Grant No. 61807023), the Youth Fund for Humanities and Social Sciences Research of the Ministry of Education (Grant No. 19YJC190023 and 17XJC190010), and the Natural Science Basic Research Plan in Shaanxi Province of China (Grant No. 2021JQ-309). SP is funded by the Royal Society. Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci: 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia. Publisher PDF
- Subjects :
- Adult
Neuroinformatics
media_common.quotation_subject
QH426 Genetics
Biology
behavioral disciplines and activities
Dyslexia
All institutes and research themes of the Radboud University Medical Center
Asian People
Reading (process)
mental disorders
medicine
Genetics
Humans
Attention deficit hyperactivity disorder
Child
Association (psychology)
QH426
Language
media_common
MCC
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
DAS
Cognition
Heritability
medicine.disease
nervous system diseases
Reading
Genetic marker
Sample size determination
genome-wide association studies
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, 54(11), 1621-1629. Nature Publishing Group, Doust, C, Fontanillas, P, Eising, E, Boomsma, D I, De Zeeuw, E L, Hottenga, J-J, Jansen, P R, Van Bergen, E, Bates, T C, Fisher, S E, Luciano, M & Quantitative Trait Working Group of the GenLang Consortium 2022, ' Discovery of 42 genome-wide significant loci associated with dyslexia ', Nature genetics, vol. 54, no. 11, pp. 1621-1629 . https://doi.org/10.1038/s41588-022-01192-y, Nature Genetics, 54, 1621-1629, Nature Genetics, 54, 11, pp. 1621-1629, Pourcain, B S, Francks, C, Marioni, R E, Zhao, J, Paracchini, S, Talcott, J B, Monaco, A P, Stein, J F, Gruen, J R, Olson, R K, Willcutt, E G, DeFries, J C, Pennington, B F, Smith, S D, Wright, M J, Martin, N G, Auton, A & Bates, T C & Fisher, S E & Luciano, M 2022, ' Discovery of 42 genome-wide significant loci associated with dyslexia ', Nature Genetics, vol. 54, no. 11, pp. 1621-1629 . https://doi.org/10.1038/s41588-022-01192-y, Nature genetics, 54(11), 1621-1629. Nature Publishing Group, Nature Genetics
- Accession number :
- edsair.doi.dedup.....4caddb680bbb6b241d270f6e52466fdb
- Full Text :
- https://doi.org/10.1038/s41588-022-01192-y