Back to Search
Start Over
Fitness costs of resistance to antimalarial drugs
- Source :
- Trends in Parasitology
- Publication Year :
- 2008
-
Abstract
- It has been recently reported that the prevalence of mutations associated with chloroquine resistance declined during the dry season. Fitness costs of drug resistance were suggested to be responsible for reduced survival of mutant parasites and only parasites surviving chronic infections were transmitted at the onset of the rainy season. This implies that during seasonal transmission significant changes can occur in allele frequency over the course of months rather than years. The practical consequences of these findings for monitoring dynamics of drug resistance markers are: (i) in areas of seasonal transmission the sampling date matters; (ii) fluctuations in mutation frequencies might be explained by seasonality; and (iii) a much awaited experimental determination of fitness costs of drug resistance becomes within reach.
- Subjects :
- Wet season
Plasmodium
030231 tropical medicine
Drug Resistance
Drug resistance
Biology
Antimalarials
03 medical and health sciences
0302 clinical medicine
Seasonal transmission
Dry season
Animals
Humans
Child
Chloroquine resistance
Allele frequency
030304 developmental biology
0303 health sciences
Resistance (ecology)
business.industry
Malaria
3. Good health
Biotechnology
Infectious Diseases
Haplotypes
Parasitology
Seasons
business
Demography
Subjects
Details
- Volume :
- 24
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Trends in Parasitology
- Accession number :
- edsair.doi.dedup.....4cac499e881f81833a67bb75f92756a5