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Immunosuppressive activities of adenosine in cancer
- Source :
- Current opinion in pharmacology. 29
- Publication Year :
- 2016
-
Abstract
- Multiple immunosuppressive mechanisms impede anti-tumor immunity. Among them, the accumulation of extracellular adenosine is a potent and widespread strategy exploited by tumors to escape immunosurveillance through the activation of purinergic receptors. In the immune system, engagement of A2a and A2b adenosine receptors is a critical regulatory mechanism that protects tissues against excessive immune reactions. In tumors, this pathway is hijacked and hinders anti-tumor immunity, promoting cancer progression. Different groups have highlighted the therapeutic potential of blocking CD73-dependent adenosine-mediated immunosuppression to reinstate anti-tumor immunity. Phase clinical trials evaluating anti-CD73 antibodies and A2a receptor antagonists in cancer patients are currently ongoing. We here review the recent literature on the immunosuppressive effects of extracellular adenosine and discuss the development of adenosine inhibitors.
- Subjects :
- 0301 basic medicine
Adenosine
Receptor, Adenosine A2A
medicine.medical_treatment
Antineoplastic Agents
Biology
Receptor, Adenosine A2B
Antibodies
03 medical and health sciences
Immune system
Immunity
Neoplasms
Drug Discovery
medicine
Animals
Humans
5'-Nucleotidase
Pharmacology
Purinergic receptor
Receptors, Purinergic
Cancer
Immunosuppression
biochemical phenomena, metabolism, and nutrition
medicine.disease
Adenosine receptor
Immunosurveillance
030104 developmental biology
Drug Design
Immunology
Disease Progression
medicine.drug
Subjects
Details
- ISSN :
- 14714973
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Current opinion in pharmacology
- Accession number :
- edsair.doi.dedup.....4ca76aaf54a4c927bb8d53260f26dafe