Supplemental Data from Using Whole-Exome Sequencing to Identify Genetic Markers for Carboplatin and Gemcitabine-Induced Toxicities

Supplemental Figure 1. Sets of variants identified with sign test and respective controls in network enrichment analysis. Supplemental Figure 2 - Genes and networks identified in the Network enrichment analysis. Supplemental Table 1 - Exome sequencing results Supplemental Table 2 A-F - Top SNVs for each bioinformatic strategy Supplemental Table 3. Genes selected from a priori knowledge of gemcitabine and carboplatin mechanism of action, transport, and metabolism. Supplemental Table 4. Summary of Ingenuity top pathways Supplemental Table 5. Patient characteristics in the validation set Supplemental Table 6. Genetic variants included in the validation