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Elevated Interleukin-6 Levels Predict Clinical Worsening in Pediatric Pulmonary Arterial Hypertension
- Source :
- J Pediatr
- Publication Year :
- 2019
-
Abstract
- Objective To assess whether circulating interleukin-6 (IL-6) is associated with measures of disease severity and clinical worsening in pediatric pulmonary arterial hypertension (PAH). Study design IL-6 was measured by enzyme-linked immunosorbent assay in serum samples from a cross-sectional cohort from the National Heart, Lung, and Blood Institute Pulmonary Arterial Hypertension Biobank (n = 175) and a longitudinal cohort from Children's Hospital Colorado (CHC) (n = 61). Associations between IL-6, disease severity, and outcomes were studied with regression and Kaplan–Meier analysis. Results In analyses adjusted for age and sex, each log-unit greater IL-6 was significantly associated in the Pulmonary Arterial Hypertension Biobank cohort with greater pulmonary vascular resistance indices, lower odds of having idiopathic PAH or treatment with prostacyclin, and greater odds of having PAH associated with a repaired congenital shunt. In the CHC cohort, each log-unit greater IL-6 was significantly associated with greater mean pulmonary arterial pressure over time. Kaplan–Meier analysis in the CHC cohort revealed that IL-6 was significantly associated with clinical worsening (a composite score of mortality, transplant, or palliative surgery) (P = .037). Conclusions IL-6 was significantly associated with worse hemodynamics at baseline and over time and may be associated with clinical worsening. IL-6 may provide a less-invasive method for disease monitoring and prognosis in pediatric PAH as well as a potential therapeutic target.
- Subjects :
- Male
medicine.medical_specialty
Composite score
Adolescent
Hemodynamics
Prostacyclin
Enzyme-Linked Immunosorbent Assay
Article
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
medicine
Humans
030212 general & internal medicine
Pulmonary Wedge Pressure
Longitudinal cohort
Interleukin 6
Child
Pulmonary Arterial Hypertension
Lung
biology
business.industry
Interleukin-6
Prognosis
medicine.anatomical_structure
Cross-Sectional Studies
Child, Preschool
Pediatrics, Perinatology and Child Health
Cohort
biology.protein
Vascular resistance
Disease Progression
Female
business
Biomarkers
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 10976833
- Volume :
- 223
- Database :
- OpenAIRE
- Journal :
- The Journal of pediatrics
- Accession number :
- edsair.doi.dedup.....4c9f907199f992d0721b3d10a1a4830d