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Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project
- Source :
- British Journal of Cancer
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Background While tobacco and alcohol are established risk factors for hepatocellular carcinoma (HCC), the most common type of primary liver cancer, it is unknown whether they also increase the risk of intrahepatic cholangiocarcinoma (ICC). Thus, we examined the association between tobacco and alcohol use by primary liver cancer type. Methods The Liver Cancer Pooling Project is a consortium of 14 US-based prospective cohort studies that includes data from 1,518,741 individuals (HCC n = 1423, ICC n = 410). Multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression. Results Current smokers at baseline had an increased risk of HCC (hazard ratio (HR) = 1.86, 95% confidence interval (CI): 1.57–2.20) and ICC (HR = 1.47, 95% CI: 1.07–2.02). Among individuals who quit smoking >30 years ago, HCC risk was almost equivalent to never smokers (HR = 1.09, 95% CI: 0.74–1.61). Compared to non-drinkers, heavy alcohol consumption was associated with an 87% increased HCC risk (HR≥7 drinks/day = 1.87, 95% CI: 1.41–2.47) and a 68% increased ICC risk (HR≥5 drinks/day = 1.68, 95% CI: 0.99–2.86). However, light-to-moderate alcohol consumption of 0–0.5–
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Carcinoma, Hepatocellular
Alcohol Drinking
medicine.medical_treatment
Gastroenterology
Article
Cholangiocarcinoma
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Tobacco
medicine
Humans
Prospective cohort study
Aged
Aged, 80 and over
business.industry
Liver Neoplasms
Smoking
Hazard ratio
Case-control study
Middle Aged
medicine.disease
Confidence interval
3. Good health
Bile Ducts, Intrahepatic
Bile Duct Neoplasms
Oncology
Case-Control Studies
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Smoking cessation
Female
030211 gastroenterology & hepatology
Liver cancer
business
Cohort study
Subjects
Details
- ISSN :
- 15321827 and 00070920
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....4c945202fb44e5e520c8bfcb2ceaccb6