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Complete genome sequence of a velogenic Newcastle disease virus isolated in Mexico
- Source :
- Virus genes. 45(2)
- Publication Year :
- 2012
-
Abstract
- In Mexico, the number of cases of the highly virulent Newcastle disease virus is increasing. In 2005, an outbreak of Newcastle disease occurred on an egg laying hen farm in the state of Puebla despite vaccination with the LaSota strain. Farmers experienced a major drop in egg production as a consequence of a field challenge virus. In this study, we characterize the virus, APMV1/chicken/Mexico/P05/2005, responsible for the outbreak. The virus is categorized as a velogenic virus with an intracranial pathogenicity index of 1.99 and a chicken embryo mean death time of 36 h. The complete genome length of the virus was sequenced as consisting of 15,192 bp. In addition, phylogenetic analysis classified the virus as a member of the class II, genotype V. The highly pathogenic nature of the virus has been linked to the amino acid sequence at the fusion protein cleavage site, which contains multiple basic amino acids (RRQKR↓F).
- Subjects :
- Genotype
Sequence analysis
Virulence Factors
viruses
Newcastle Disease
Molecular Sequence Data
Newcastle disease virus
Virulence
Genome, Viral
Biology
Genome
Newcastle disease
Virus
Disease Outbreaks
Virology
Genetics
Animals
Molecular Biology
Peptide sequence
Mexico
Poultry Diseases
Outbreak
General Medicine
Sequence Analysis, DNA
biology.organism_classification
RNA, Viral
Chickens
Viral Fusion Proteins
Subjects
Details
- ISSN :
- 1572994X
- Volume :
- 45
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Virus genes
- Accession number :
- edsair.doi.dedup.....4c93264a251efe63b6d03ac1029ef1cd