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Supplementary materials and methods, figures and legends from Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression

Authors :
Antonio Sica
Luigi Laghi
Emilio Hirsch
Emilia Turco
Stefania Vetrano
Fiorella Balzac
Paolo Bianchi
Maurizio Rinaldi
Silvia Tartari
Fabio Pasqualini
Fabio Grizzi
Carmen Correale
Giuseppe Celesti
Lorenzo Carraro
Francesca Maria Consonni
Alessandro Ippolito
Chiara Porta
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

S1: Analysis of p50 NF-κB ablation in myeloid cells (p50Fl/Fl; Lyz2Cre mice) and enterocytes (p50Fl/Fl; VillinCre mice). S2: Analysis of inflammatory gene expression at different phases of colitisassociated CRC (CAC) development. S3: Lack of p50 NF-κB exacerbates DSS-induced colitis. S4: Genetic ablation of p50 unleashes anti-tumor M1-polarized activation of TAMs. S5: Lack of p50 shapes gut associated immune populations in AOM/DSS treated. S6: Lack of p50 selectively impairs lamina propria monocytes/macrophages accumulation in steady state conditions. mice. S7: Wt and p50-/- mice show similar levels of proliferative colonic cancer cells. S8: Nuclear accumulation of p50 in TAM at the inner tumor tissue does not correlate with CRC patients' outcome.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....4c923fe5026a60dfbb610843e9d45306
Full Text :
https://doi.org/10.1158/2326-6066.22535908