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Supplementary materials and methods, figures and legends from Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression
- Publication Year :
- 2023
- Publisher :
- American Association for Cancer Research (AACR), 2023.
-
Abstract
- S1: Analysis of p50 NF-κB ablation in myeloid cells (p50Fl/Fl; Lyz2Cre mice) and enterocytes (p50Fl/Fl; VillinCre mice). S2: Analysis of inflammatory gene expression at different phases of colitisassociated CRC (CAC) development. S3: Lack of p50 NF-κB exacerbates DSS-induced colitis. S4: Genetic ablation of p50 unleashes anti-tumor M1-polarized activation of TAMs. S5: Lack of p50 shapes gut associated immune populations in AOM/DSS treated. S6: Lack of p50 selectively impairs lamina propria monocytes/macrophages accumulation in steady state conditions. mice. S7: Wt and p50-/- mice show similar levels of proliferative colonic cancer cells. S8: Nuclear accumulation of p50 in TAM at the inner tumor tissue does not correlate with CRC patients' outcome.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4c923fe5026a60dfbb610843e9d45306
- Full Text :
- https://doi.org/10.1158/2326-6066.22535908