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Index60 Identifies Individuals at Appreciable Risk for Stage 3 Among an Autoantibody-Positive Population With Normal 2-Hour Glucose Levels: Implications for Current Staging Criteria of Type 1 Diabetes
Index60 Identifies Individuals at Appreciable Risk for Stage 3 Among an Autoantibody-Positive Population With Normal 2-Hour Glucose Levels: Implications for Current Staging Criteria of Type 1 Diabetes
- Source :
- Diabetes Care
- Publication Year :
- 2021
- Publisher :
- American Diabetes Association, 2021.
-
Abstract
- OBJECTIVE We assessed whether Index60, a composite measure of fasting C-peptide, 60-min C-peptide, and 60-min glucose, could improve the metabolic staging of type 1 diabetes for progression to clinical disease (stage 3) among autoantibody-positive (Ab+) individuals with normal 2-h glucose values ( RESEARCH DESIGN AND METHODS We analyzed 3,058 Type 1 Diabetes TrialNet Pathway to Prevention participants with 2-h glucose RESULTS HI-IND60 and HI-BOTH were younger, with greater frequency of more than two Ab+, and lower C-peptide levels, than either HI-2HGLU or LO-BOTH (all P < 0.001). The cumulative incidence for stage 3 was greater for HI-IND60 and HI-BOTH than for either HI-2HGLU or LO-BOTH (all P < 0.001). Those with Index60 values above the median were younger and had higher frequency of two or more Ab+ (P < 0.001) and DR3-DQ2/DR4-DQ8 prevalence (P < 0.001) and lower area under the curve (AUC) C-peptide levels (P < 0.001) than those below. Those above the 2-h glucose median had higher AUC C-peptide levels (P < 0.001), but otherwise did not differ from those below. CONCLUSIONS Index60 identifies individuals with characteristics of type 1 diabetes at appreciable risk for progression who would otherwise be missed by 2-h glucose staging criteria.
- Subjects :
- Blood Glucose
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Population
Gastroenterology
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Humans
Cumulative incidence
Epidemiology/Health Services Research
Stage (cooking)
education
Autoantibodies
Advanced and Specialized Nursing
Type 1 diabetes
education.field_of_study
C-Peptide
business.industry
Autoantibody
Area under the curve
Glucose Tolerance Test
medicine.disease
Diabetes Mellitus, Type 1
Glucose
Quartile
business
Subjects
Details
- ISSN :
- 01495992
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....4c90ebaa5ad1ca3fadd923c981dbfaf8
- Full Text :
- https://doi.org/10.2337/dc21-0944