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Exercise effects on polyp burden and immune markers in the ApcMin/+ mouse model of intestinal tumorigenesis
- Source :
- International Journal of Oncology
- Publication Year :
- 2014
- Publisher :
- Spandidos Publications, 2014.
-
Abstract
- Many observational epidemiologic studies suggest an association between exercise and colon cancer risk. The mechanisms contributing to a preventative effect of exercise on colon cancer are complex and multifaceted. Altered immune system function is one possible mechanism that has been largely unexplored. Therefore, the purpose of this study was to examine the effects of exercise on markers associated with macrophages and select T cell populations in a mouse model of intestinal tumorigenesis and to relate this to polyp characteristics. Male Apc(Min/+) mice were randomly assigned to either sedentary (Sed) or exercise (Ex) treatment (n=6-9/group). The exercise treatment consisted of treadmill running for 1 h/day and 6 days a week at 15 m/min from 4 until 16 weeks of age. Intestinal polyps were counted and categorized by size. Mucosal tissue was analyzed for mRNA expression of overall macrophages (F4/80), for genes associated with M1 (IL-12, IL-23 and Nos2) and M2 (CD206, IL-10, IL-4, CCL17, CCL22 and Arg-1) macrophages and the macrophage chemoattractants MCP-1, fetuin A and CXCL14. Markers for cytotoxic T cells (CTLs) and regulatory T cells were also examined by measuring mRNA expression of CD8 and Foxp3, respectively. While there was no significant difference in overall polyp number between the groups (Sed, 23.3±4.3; and Ex, 16.5±4.3), Ex did have a reduction in the number of large polyps (Sed, 6.1±1.1; and Ex, 3.0±0.6) (P
- Subjects :
- Cancer Research
medicine.medical_specialty
Colorectal cancer
T-Lymphocytes
T cell
T cells
physical activity
colorectal cancer
Spleen
Motor Activity
Biology
Mice
Immune system
immune markers
T-Lymphocyte Subsets
Internal medicine
medicine
Animals
Cytotoxic T cell
exercise
Macrophages
Intestinal Polyps
FOXP3
Articles
medicine.disease
Mice, Mutant Strains
Mice, Inbred C57BL
Disease Models, Animal
Cell Transformation, Neoplastic
medicine.anatomical_structure
Endocrinology
Oncology
Colonic Neoplasms
Disease Progression
Precancerous Conditions
CCL22
CD8
Subjects
Details
- ISSN :
- 17912423 and 10196439
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- International Journal of Oncology
- Accession number :
- edsair.doi.dedup.....4c882cc55a1786f87bcbe362ac79224a